Ontology highlight
ABSTRACT:
SUBMITTER: Naylor AS
PROVIDER: S-EPMC2567198 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Naylor Andrew S AS Bull Cecilia C Nilsson Marie K L MK Zhu Changlian C Björk-Eriksson Thomas T Eriksson Peter S PS Blomgren Klas K Kuhn H Georg HG
Proceedings of the National Academy of Sciences of the United States of America 20080902 38
Cranial radiation therapy is commonly used in the treatment of childhood cancers. It is associated with cognitive impairments tentatively linked to the hippocampus, a neurogenic region of the brain important in memory function and learning. Hippocampal neurogenesis is positively regulated by voluntary exercise, which is also known to improve hippocampal-dependent cognitive functions. In this work, we irradiated the brains of C57/BL6 mice on postnatal day 9 and evaluated both the acute effects of ...[more]