Ontology highlight
ABSTRACT:
SUBMITTER: Sanz LA
PROVIDER: S-EPMC2567399 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Sanz Lionel A LA Chamberlain Stormy S Sabourin Jean-Charles JC Henckel Amandine A Magnuson Terry T Hugnot Jean-Philippe JP Feil Robert R Arnaud Philippe P
The EMBO journal 20080724 19
Genomic imprinting is a developmental mechanism that mediates parent-of-origin-specific expression in a subset of genes. How the tissue specificity of imprinted gene expression is controlled remains poorly understood. As a model to address this question, we studied Grb10, a gene that displays brain-specific expression from the paternal chromosome. Here, we show in the mouse that the paternal promoter region is marked by allelic bivalent chromatin enriched in both H3K4me2 and H3K27me3, from early ...[more]