Ontology highlight
ABSTRACT:
SUBMITTER: Forman JJ
PROVIDER: S-EPMC2567461 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Forman Joshua J JJ Legesse-Miller Aster A Coller Hilary A HA
Proceedings of the National Academy of Sciences of the United States of America 20080923 39
Recognition sites for microRNAs (miRNAs) have been reported to be located in the 3' untranslated regions of transcripts. In a computational screen for highly conserved motifs within coding regions, we found an excess of sequences conserved at the nucleotide level within coding regions in the human genome, the highest scoring of which are enriched for miRNA target sequences. To validate our results, we experimentally demonstrated that the let-7 miRNA directly targets the miRNA-processing enzyme D ...[more]