Ontology highlight
ABSTRACT:
SUBMITTER: Lai Kwan Lam Q
PROVIDER: S-EPMC2567481 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Lai Kwan Lam Queenie Q King Hung Ko Otis O Zheng Bo-Jian BJ Lu Liwei L
Proceedings of the National Academy of Sciences of the United States of America 20080926 39
Rheumatoid arthritis (RA) is a chronic disease characterized by synovial inflammation and joint damage. Although both T cells and B cells mediate the disease pathogenesis, proinflammatory cytokines are critically involved. The TNF superfamily member B cell-activating factor (BAFF) plays an important role in humoral immunity and in autoimmune diseases, including RA. Here, we show that intra-articular injection of lentivirus expressing shRNA for BAFF gene silencing provides long-term suppression o ...[more]