Ontology highlight
ABSTRACT:
SUBMITTER: Fourcaudot E
PROVIDER: S-EPMC2567504 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Fourcaudot Elodie E Gambino Frédéric F Humeau Yann Y Casassus Guillaume G Shaban Hamdy H Poulain Bernard B Lüthi Andreas A
Proceedings of the National Academy of Sciences of the United States of America 20080924 39
NMDA receptor-dependent long-term potentiation (LTP) of glutamatergic synaptic transmission in sensory pathways from auditory thalamus or cortex to the lateral amygdala (LA) underlies the acquisition of auditory fear conditioning. Whereas the mechanisms of postsynaptic LTP at thalamo-LA synapses are well understood, much less is known about the sequence of events mediating presynaptic NMDA receptor-dependent LTP at cortico-LA synapses. Here, we show that presynaptic cortico-LA LTP can be entirel ...[more]