Ontology highlight
ABSTRACT:
SUBMITTER: Sakisaka T
PROVIDER: S-EPMC2568027 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Sakisaka Toshiaki T Yamamoto Yasunori Y Mochida Sumiko S Nakamura Michiko M Nishikawa Kouki K Ishizaki Hiroyoshi H Okamoto-Tanaka Miki M Miyoshi Jun J Fujiyoshi Yoshinori Y Manabe Toshiya T Takai Yoshimi Y
The Journal of cell biology 20081001 2
Neurotransmitter release from presynaptic nerve terminals is regulated by soluble NSF attachment protein receptor (SNARE) complex-mediated synaptic vesicle fusion. Tomosyn inhibits SNARE complex formation and neurotransmitter release by sequestering syntaxin-1 through its C-terminal vesicle-associated membrane protein (VAMP)-like domain (VLD). However, in tomosyn-deficient mice, the SNARE complex formation is unexpectedly decreased. In this study, we demonstrate that the N-terminal WD-40 repeat ...[more]