Ontology highlight
ABSTRACT:
SUBMITTER: Fritz R
PROVIDER: S-EPMC2568029 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Fritz Richard R Stiasny Karin K Heinz Franz X FX
The Journal of cell biology 20081001 2
The flavivirus membrane fusion machinery, like that of many other enveloped viruses, is triggered by the acidic pH in endosomes after virus uptake by receptor-mediated endocytosis. It has been hypothesized that conserved histidines in the class II fusion protein E of these viruses function as molecular switches and, by their protonation, control the fusion process. Using the mutational analysis of recombinant subviral particles of tick-borne encephalitis virus, we provide direct experimental evi ...[more]