Chemical dissection of the link between streptozotocin, O-GlcNAc, and pancreatic cell death.
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ABSTRACT:
SUBMITTER: Pathak S
PROVIDER: S-EPMC2568864 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
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Chemical dissection of the link between streptozotocin, O-GlcNAc, and pancreatic cell death.
Pathak Shalini S Dorfmueller Helge C HC Borodkin Vladimir S VS van Aalten Daan M F DM
Chemistry & biology 20080801 8
Streptozotocin is a natural product that selectively kills insulin-secreting beta cells, and is widely used to generate mouse models of diabetes or treat pancreatic tumors. Several studies suggest that streptozotocin toxicity stems from its N-nitrosourea moiety releasing nitric oxide and possessing DNA alkylating activity. However, it has also been proposed that streptozotocin induces apoptosis by inhibiting O-GlcNAcase, an enzyme that, together with O-GlcNAc transferase, is important for dynami ...[more]
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