Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters.
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ABSTRACT:
SUBMITTER: Pruunsild P
PROVIDER: S-EPMC2568880 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Publications
Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters.
Pruunsild Priit P Kazantseva Anna A Aid Tamara T Palm Kaia K Timmusk Tõnis T
Genomics 20070712 3
Brain-derived neurotrophic factor (BDNF), a member of the nerve growth factor family of neurotrophins, has central roles in the development, physiology, and pathology of the nervous system. We have elucidated the structure of the human BDNF gene, identified alternative transcripts, and studied their expression in adult human tissues and brain regions. In addition, the transcription initiation sites for human BDNF transcripts were determined and the activities of BDNF promoters were analyzed in t ...[more]
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