Ontology highlight
ABSTRACT:
SUBMITTER: Hasko G
PROVIDER: S-EPMC2568887 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Nature reviews. Drug discovery 20080901 9
Adenosine is a key endogenous molecule that regulates tissue function by activating four G-protein-coupled adenosine receptors: A1, A2A, A2B and A3. Cells of the immune system express these receptors and are responsive to the modulatory effects of adenosine in an inflammatory environment. Animal models of asthma, ischaemia, arthritis, sepsis, inflammatory bowel disease and wound healing have helped to elucidate the regulatory roles of the various adenosine receptors in dictating the development ...[more]