Ontology highlight
ABSTRACT:
SUBMITTER: Kauppi M
PROVIDER: S-EPMC2569170 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Kauppi Maria M Murphy James M JM de Graaf Carolyn A CA Hyland Craig D CD Greig Kylie T KT Metcalf Donald D Hilton Adrienne A AA Nicola Nicos A NA Kile Benjamin T BT Hilton Douglas J DJ Alexander Warren S WS
Blood 20080806 8
In an N-nitroso-N-ethylurea (ENU) mutagenesis screen using Mpl(-/-) mice, we isolated a semidominant suppressor of thrombocytopenia, termed Plt6. The gene mutated in Plt6 mice encodes the transcriptional coregulator p300, and the mutation, a tyrosine to asparagine substitution at amino acid 630 (Y630N), disrupts the interaction between p300 and c-Myb. Mpl(-/-) p300(Plt6/+) mice displayed elevated platelet counts relative to Mpl(-/-) p300(+/+) controls, whereas mice homozygous for the Plt6 mutati ...[more]