Ontology highlight
ABSTRACT:
SUBMITTER: Raetz CR
PROVIDER: S-EPMC2569861 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Annual review of biochemistry 20070101
The lipid A moiety of lipopolysaccharide forms the outer monolayer of the outer membrane of most gram-negative bacteria. Escherichia coli lipid A is synthesized on the cytoplasmic surface of the inner membrane by a conserved pathway of nine constitutive enzymes. Following attachment of the core oligosaccharide, nascent core-lipid A is flipped to the outer surface of the inner membrane by the ABC transporter MsbA, where the O-antigen polymer is attached. Diverse covalent modifications of the lipi ...[more]