Ontology highlight
ABSTRACT:
SUBMITTER: Zhang YH
PROVIDER: S-EPMC2570586 | biostudies-literature | 2006 Sep
REPOSITORIES: biostudies-literature
Zhang Yu-Hui YH Ginsberg Cynthia C Yuan Yanqiu Y Walker Suzanne S
Biochemistry 20060901 36
Wall teichoic acids (WTAs) are anionic polymers that coat the cell walls of Gram-positive bacteria. Because they are essential for survival or virulence in many organisms, the enzymes involved in the biosynthesis of WTAs are attractive antibiotic targets. The first committed step in the WTA biosynthetic pathway in Bacillus subtilis is catalyzed by TagA, which transfers N-acetylmannosamine (ManNAc) to the C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid (GlcNAc-pp-undecapren ...[more]