Ontology highlight
ABSTRACT:
SUBMITTER: Gorringe KL
PROVIDER: S-EPMC2570601 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Gorringe Kylie L KL Choong David Yh DY Williams Louise H LH Ramakrishna Manasa M Sridhar Anita A Qiu Wen W Bearfoot Jennifer L JL Campbell Ian G IG
Neoplasia (New York, N.Y.) 20081101 11
Chromodomain, helicase, DNA binding 5 (CHD5) is a member of a subclass of the chromatin remodeling Swi/Snf proteins and has recently been proposed as a tumor suppressor in a diverse range of human cancers. We analyzed all 41 coding exons of CHD5 for somatic mutations in 123 primary ovarian cancers as well as 60 primary breast cancers using high-resolution melt analysis. We also examined methylation of the CHD5 promoter in 48 ovarian cancer samples by methylation-specific single-stranded conforma ...[more]