Ontology highlight
ABSTRACT:
SUBMITTER: Andre I
PROVIDER: S-EPMC2570982 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
André Ingemar I Strauss Charlie E M CE Kaplan David B DB Bradley Philip P Baker David D
Proceedings of the National Academy of Sciences of the United States of America 20081010 42
Naturally occurring homooligomeric protein complexes exhibit striking internal symmetry. The evolutionary origins of this symmetry have been the subject of considerable speculation; proposals for the advantages associated with symmetry include greater folding efficiency, reduced aggregation, amenability to allosteric regulation, and greater adaptability. An alternative possibility stems from the idea that to contribute to fitness, and hence be subject to evolutionary optimization, a complex must ...[more]