Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver.

ABSTRACT: Genomic hypomethylation is a consistent finding in both human and animal tumors and mounting experimental evidence suggests a key role for epigenetic events in tumorigenesis. Furthermore, it has been suggested that early changes in DNA methylation and histone modifications may serve as sensitive predictive markers in animal testing for carcinogenic potency of environmental agents. Alterations in metabolism of methyl donors, disturbances in activity and/or expression of DNA methyltransferases, and presence of DNA single-strand breaks could contribute to the loss of cytosine methylation during carcinogenesis; however, the precise mechanisms of genomic hypomethylation induced by chemical carcinogens remain largely unknown. This study examined the mechanism of DNA hypomethylation during hepato

SUBMITTER: Pogribny IP 

PROVIDER: S-EPMC2571982 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature