Reorganization of visual processing in macular degeneration: replication and clues about the role of foveal loss.
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ABSTRACT:
SUBMITTER: Baker CI
PROVIDER: S-EPMC2572262 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
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Reorganization of visual processing in macular degeneration: replication and clues about the role of foveal loss.
Baker Chris I CI Dilks Daniel D DD Peli Eli E Kanwisher Nancy N
Vision research 20080711 18
We previously reported large-scale reorganization of visual processing (i.e., activation of "foveal" cortex by peripheral stimuli) in two individuals with loss of foveal input from macular degeneration [Baker, C.I., Peli, E., Knouf, N., & Kanwisher, N. G. (2005). Reorganization of visual processing in macular degeneration. Journal of Neuroscience, 25(3), 614-618]. Here, we replicate this result in three new individuals. Further, we test the hypothesis that this reorganization is dependent on com ...[more]
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Project description:PurposeTo assess the relationship between cone spacing and visual acuity in eyes with rod-cone degeneration (RCD) followed longitudinally.MethodsHigh-resolution images of the retina were obtained using adaptive optics scanning laser ophthalmoscopy from 13 eyes of nine RCD patients and 13 eyes of eight healthy subjects at two sessions separated by 10 or more months (mean 765 days, range 311-1935 days). Cone spacing Z-score measured as close as possible (average <0.25°) to the preferred retinal locus was compared with visual acuity (letters read on the Early Treatment of Diabetic Retinopathy Study [ETDRS] chart and logMAR) and foveal sensitivity.ResultsCone spacing was significantly correlated with ETDRS letters read (ρ = -0.47, 95%CI -0.67 to -0.24), logMAR (ρ = 0.46, 95%CI 0.24 to 0.66), and foveal sensitivity (ρ = -0.30, 95%CI -0.52 to -0.018). There was a small but significant increase in mean cone spacing Z-score during follow-up of +0.97 (95%CI 0.57 to 1.4) in RCD patients, but not in healthy eyes, and there was no significant change in any measure of visual acuity.ConclusionsCone spacing was correlated with visual acuity and foveal sensitivity. In RCD patients, cone spacing increased during follow-up, while visual acuity did not change significantly. Cone spacing Z-score may be a more sensitive measure of cone loss at the fovea than visual acuity in patients with RCD.
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