Ontology highlight
ABSTRACT:
SUBMITTER: Ross DG
PROVIDER: S-EPMC2572636 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Ross Diana G F DG Bowles Josephine J Koopman Peter P Lehnert Sigrid S
BMC molecular biology 20081014
<h4>Background</h4>SRY is the pivotal gene initiating male sex determination in most mammals, but how its expression is regulated is still not understood. In this study we derived novel SRY 5' flanking genomic sequence data from bovine and caprine genomic BAC clones.<h4>Results</h4>We identified four intervals of high homology upstream of SRY by comparison of human, bovine, pig, goat and mouse genomic sequences. These conserved regions contain putative binding sites for a large number of known t ...[more]