Genomics and genome-wide association studies: an integrative approach to expression QTL mapping.
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ABSTRACT:
SUBMITTER: Degnan JH
PROVIDER: S-EPMC2572725 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Publications
Genomics and genome-wide association studies: an integrative approach to expression QTL mapping.
Degnan James H JH Lasky-Su Jessica J Raby Benjamin A BA Xu Mousheng M Molony Cliona C Schadt Eric E EE Lange Christoph C
Genomics 20080630 3
Expression QTL mapping by integrating genome-wide gene expression and genotype data is a promising approach to identifying functional genetic variation, but is hampered by the large number of multiple comparisons inherent in such studies. A novel approach to addressing multiple testing problems in genome-wide family-based association studies is screening candidate markers using heritability or conditional power. We apply these methods in settings in which microarray gene expression data are used ...[more]
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