A functional nitric oxide reductase model.
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ABSTRACT:
SUBMITTER: Collman JP
PROVIDER: S-EPMC2572950 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Publications
A functional nitric oxide reductase model.
Collman James P JP Yang Ying Y Dey Abhishek A Decréau Richard A RA Ghosh Somdatta S Ohta Takehiro T Solomon Edward I EI
Proceedings of the National Academy of Sciences of the United States of America 20081006 41
A functional heme/nonheme nitric oxide reductase (NOR) model is presented. The fully reduced diiron compound reacts with two equivalents of NO leading to the formation of one equivalent of N(2)O and the bis-ferric product. NO binds to both heme Fe and nonheme Fe complexes forming individual ferrous nitrosyl species. The mixed-valence species with an oxidized heme and a reduced nonheme Fe(B) does not show NO reduction activity. These results are consistent with a so-called "trans" mechanism for t ...[more]
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