Ontology highlight
ABSTRACT:
SUBMITTER: Maghsoodi B
PROVIDER: S-EPMC2572971 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Maghsoodi Bita B Poon Michael M MM Nam Christine I CI Aoto Jason J Ting Pamela P Chen Lu L
Proceedings of the National Academy of Sciences of the United States of America 20081007 41
Homeostatic plasticity is thought to play an important role in maintaining the stability of neuronal circuits. During one form of homeostatic plasticity, referred to as synaptic scaling, activity blockade leads to a compensatory increase in synaptic transmission by stimulating in dendrites the local translation and synaptic insertion of the AMPA receptor subunit GluR1. We have previously shown that all-trans retinoic acid (RA) mediates activity blockade-induced synaptic scaling by activating den ...[more]