Ontology highlight
ABSTRACT:
SUBMITTER: Harvey SJ
PROVIDER: S-EPMC2573015 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Harvey Scott J SJ Jarad George G Cunningham Jeanette J Goldberg Seth S Schermer Bernhard B Harfe Brian D BD McManus Michael T MT Benzing Thomas T Miner Jeffrey H JH
Journal of the American Society of Nephrology : JASN 20080905 11
MicroRNAs (miRNAs) regulate gene expression by binding the 3' untranslated region of mRNAs. To define their role in glomerular function, miRNA biogenesis was disrupted in mouse podocytes using a conditional Dicer allele. Mutant mice developed proteinuria by 3 wk after birth and progressed rapidly to end-stage kidney disease. Podocyte pathology included effacement, vacuolization, and hypertrophy with crescent formation. Despite normal expression of WT1, podocytes underwent dedifferentiation, exem ...[more]