Ontology highlight
ABSTRACT:
SUBMITTER: Kempf L
PROVIDER: S-EPMC2573019 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Kempf Lucas L Nicodemus Kristin K KK Kolachana Bhaskar B Vakkalanka Radhakrishna R Verchinski Beth A BA Egan Michael F MF Straub Richard E RE Mattay Venkata A VA Callicott Joseph H JH Weinberger Daniel R DR Meyer-Lindenberg Andreas A
PLoS genetics 20081107 11
PRODH, encoding proline oxidase (POX), has been associated with schizophrenia through linkage, association, and the 22q11 deletion syndrome (Velo-Cardio-Facial syndrome). Here, we show in a family-based sample that functional polymorphisms in PRODH are associated with schizophrenia, with protective and risk alleles having opposite effects on POX activity. Using a multimodal imaging genetics approach, we demonstrate that haplotypes constructed from these risk and protective functional polymorphis ...[more]