Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez-Guerrero M
PROVIDER: S-EPMC2573086 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
González-Guerrero Manuel M Eren Elif E Rawat Swati S Stemmler Timothy L TL Argüello José M JM
The Journal of biological chemistry 20080904 44
Cu(+)-ATPases drive metal efflux from the cell cytoplasm. Paramount to this function is the binding of Cu(+) within the transmembrane region and its coupled translocation across the permeability barrier. Here, we describe the two transmembrane Cu(+) transport sites present in Archaeoglobus fulgidus CopA. Both sites can be independently loaded with Cu(+). However, their simultaneous occupation is associated with enzyme turnover. Site I is constituted by two Cys in transmembrane segment (TM) 6 and ...[more]