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Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae.

ABSTRACT: Fluoroquinolone resistance in Streptococcus pneumoniae mainly involves stepwise mutations predominantly in the parC and gyrA genes. We have developed a single-run real-time PCR assay for detection of the four most common mutations in the quinolone resistance-determining regions of these genes. This assay provides a useful tool for both clinical and epidemiological use.

SUBMITTER: Page S 

PROVIDER: S-EPMC2573127 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature

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Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae.

Page S S   Vernel-Pauillac F F   O'Connor O O   Bremont S S   Charavay F F   Courvalin P P   Goarant C C   Le Hello S S  

Antimicrobial agents and chemotherapy 20080825 11

Fluoroquinolone resistance in Streptococcus pneumoniae mainly involves stepwise mutations predominantly in the parC and gyrA genes. We have developed a single-run real-time PCR assay for detection of the four most common mutations in the quinolone resistance-determining regions of these genes. This assay provides a useful tool for both clinical and epidemiological use. ...[more]

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