Ontology highlight
ABSTRACT:
SUBMITTER: Chan YL
PROVIDER: S-EPMC2573197 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Chan Yi-Lin YL Chang Tsung-Hsien TH Liao Ching-Len CL Lin Yi-Ling YL
Journal of virology 20080903 21
Viperin is identified as an antiviral protein induced by interferon (IFN), viral infections, and pathogen-associated molecules. In this study, we found that viperin is highly induced at the RNA level by Japanese encephalitis virus (JEV) and Sindbis virus (SIN) and that viperin protein is degraded in JEV-infected cells through a proteasome-dependent mechanism. Promoter analysis revealed that SIN induces viperin expression in an IFN-dependent manner but that JEV by itself activates the viperin pro ...[more]