Crystal structure of the avian reovirus inner capsid protein sigmaA.
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ABSTRACT:
SUBMITTER: Guardado-Calvo P
PROVIDER: S-EPMC2573251 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Publications
Crystal structure of the avian reovirus inner capsid protein sigmaA.
Guardado-Calvo Pablo P Vazquez-Iglesias Lorena L Martinez-Costas José J Llamas-Saiz Antonio L AL Schoehn Guy G Fox Gavin C GC Hermo-Parrado X Lois XL Benavente Javier J van Raaij Mark J MJ
Journal of virology 20080917 22
Avian reovirus, an important avian pathogen, expresses eight structural and four nonstructural proteins. The structural sigmaA protein is a major component of the inner capsid, clamping together lambdaA building blocks. sigmaA has also been implicated in the resistance of avian reovirus to the antiviral action of interferon by strongly binding double-stranded RNA in the host cell cytoplasm and thus inhibiting activation of the double-stranded RNA-dependent protein kinase. We have solved the stru ...[more]
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