Ontology highlight
ABSTRACT:
SUBMITTER: Kader M
PROVIDER: S-EPMC2573260 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Kader Muhamuda M Hassan Wail M WM Eberly Matthew M Piatak Michael M Lifson Jeffrey D JD Roederer Mario M Mattapallil Joseph J JJ
Journal of virology 20080903 22
The rectal mucosa is a major site for human immunodeficiency virus entry and CD4 T-cell depletion. The early and near-total loss of these cells from the rectal mucosa severely compromises the ability of the mucosal immune system to control various opportunistic infections. Protecting these cells from infection and destruction can delay disease progression, leading to a better long-term outcome. Here we show that effective suppression of viral infection in memory CD4 T cells from the rectal mucos ...[more]