Ontology highlight
ABSTRACT:
SUBMITTER: Kalsotra A
PROVIDER: S-EPMC2574503 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Kalsotra Auinash A Anakk Sayeepriyadarshini S Brommer Chad L CL Kikuta Yasushi Y Morgan Edward T ET Strobel Henry W HW
Archives of biochemistry and biophysics 20070315 1
Cytochrome P450 (CYP) 4F mediated leukotriene B(4) (LTB(4)) metabolism modulates inflammation during injury and infection. Here we show that in addition to LTB(4), the recombinant rat CYP4Fs catalyze omega-hydroxylations of lipoxin A(4), and hydroxyeicosatetraeonic acids. CYP4F gene regulation studies in primary hepatocytes reveal that pro-inflammatory cytokines interleukin (IL) -1beta, IL-6 and tumor necrosis factor (TNF) -alpha produce a general inductive response whereas IL-10, an anti-inflam ...[more]