Ontology highlight
ABSTRACT:
SUBMITTER: Song IS
PROVIDER: S-EPMC2574735 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Song Im-Sook IS Chen Helen H W HH Aiba Isamu I Hossain Anwar A Liang Zheng D ZD Klomp Leo W J LW Kuo Macus Tien MT
Molecular pharmacology 20080515 3
Copper is an essential metal nutrient, yet copper overload is toxic. Here, we report that human copper transporter (hCtr) 1 plays an important role in the maintenance of copper homeostasis by demonstrating that expression of hCtr1 mRNA was up-regulated under copper-depleted conditions and down-regulated under copper-replete conditions. Overexpression of full-length hCtr1 by transfection with a recombinant hCtr1 cDNA clone reduced endogenous hCtr1 mRNA levels, whereas overexpression of N terminus ...[more]