Ontology highlight
ABSTRACT:
SUBMITTER: Wen L
PROVIDER: S-EPMC2574766 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Wen Li L Ley Ruth E RE Volchkov Pavel Yu PY Stranges Peter B PB Avanesyan Lia L Stonebraker Austin C AC Hu Changyun C Wong F Susan FS Szot Gregory L GL Bluestone Jeffrey A JA Gordon Jeffrey I JI Chervonsky Alexander V AV
Nature 20080921 7216
Type 1 diabetes (T1D) is a debilitating autoimmune disease that results from T-cell-mediated destruction of insulin-producing beta-cells. Its incidence has increased during the past several decades in developed countries, suggesting that changes in the environment (including the human microbial environment) may influence disease pathogenesis. The incidence of spontaneous T1D in non-obese diabetic (NOD) mice can be affected by the microbial environment in the animal housing facility or by exposur ...[more]