Mutation in TERT separates processivity from anchor-site function.
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ABSTRACT:
SUBMITTER: Zaug AJ
PROVIDER: S-EPMC2574958 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Publications
Mutation in TERT separates processivity from anchor-site function.
Zaug Arthur J AJ Podell Elaine R ER Cech Thomas R TR
Nature structural & molecular biology 20080720 8
Telomerase shows repeat-addition processivity (RAP): synthesis of multiple telomeric DNA repeats without primer dissociation. Leu14 mutants in the telomerase essential N-terminal domain of Tetrahymena thermophila telomerase reverse transcriptase retain full activity and anchor-site function but lose RAP, suggesting models for how this domain facilitates DNA translocation. ...[more]
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