Ontology highlight
ABSTRACT:
SUBMITTER: Lu X
PROVIDER: S-EPMC2575085 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Lu Xiaobing X Zhang Yinghui Y Shin Yeon-Kyun YK
Nature structural & molecular biology 20080615 7
Formation of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex facilitates intracellular membrane fusion. A single SNARE complex is thought to be insufficient; multiple copies of SNARE complexes must work cooperatively. However, the mechanism by which such a higher-order SNARE protein structure is assembled is unknown. EPR and fluorescence analyses show that at least three copies of target-membrane SNARE proteins self-assemble through the interaction betwe ...[more]