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Pea3 expression is regulated by FGF signaling in developing retina.

ABSTRACT: FGF signaling has been implicated as an important regulator of retinal development. As a first step in characterizing potential downstream targets of FGF signaling in the retina, we have analyzed expression of Pea3, a member of the Pea3 class of Ets-domain transcription factors, in the developing eye. We find that Pea3 is expressed in the developing retina, and its transcription is regulated by FGF receptor activation. In addition, FGF signaling activates Cath5, a gene necessary for retinal ganglion cell differentiation. These results suggest that FGF signaling via MAPK up-regulates transcription factors that in turn control retinal ganglion cell differentiation.

SUBMITTER: McCabe KL

PROVIDER: S-EPMC2575118 | biostudies-literature | 2006 Feb

REPOSITORIES: biostudies-literature

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Pea3 expression is regulated by FGF signaling in developing retina.

McCabe Kathryn Leigh KL McGuire Chris C Reh Thomas A TA

Developmental dynamics : an official publication of the American Association of Anatomists 20060201 2

FGF signaling has been implicated as an important regulator of retinal development. As a first step in characterizing potential downstream targets of FGF signaling in the retina, we have analyzed expression of Pea3, a member of the Pea3 class of Ets-domain transcription factors, in the developing eye. We find that Pea3 is expressed in the developing retina, and its transcription is regulated by FGF receptor activation. In addition, FGF signaling activates Cath5, a gene necessary for retinal gang ...[more]

PMID: 16273524

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