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Toward the synthesis of cobyric acid. Enantioselective syntheses of completely differentiated ring D synthons.

ABSTRACT: Alkyne acids 11 were prepared in an enantioselective fashion from allylic ester derivatives 18 or 20 by Ireland-Claisen rearrangement, followed by Si-assisted elimination of HBr. The title compounds are attractive ring D synthons for an ongoing synthesis of cobyric acid.

SUBMITTER: Wang H

PROVIDER: S-EPMC2575186 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature

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Toward the synthesis of cobyric acid. Enantioselective syntheses of completely differentiated ring D synthons.

Wang Hui H Tassa Carlos C Jacobi Peter A PA

Organic letters 20080607 13

Alkyne acids 11 were prepared in an enantioselective fashion from allylic ester derivatives 18 or 20 by Ireland-Claisen rearrangement, followed by Si-assisted elimination of HBr. The title compounds are attractive ring D synthons for an ongoing synthesis of cobyric acid. ...[more]

PMID: 18537250

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