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MotifCluster: an interactive online tool for clustering and visualizing sequences using shared motifs.


ABSTRACT: MotifCluster finds related motifs in a set of sequences, and clusters the sequences into families using the motifs they contain. MotifCluster, at http://bmf.colorado.edu/motifcluster, lets users test whether proteins are related, cluster sequences by shared conserved motifs, and visualize motifs mapped onto trees, sequences and three-dimensional structures. We demonstrate MotifCluster's accuracy using gold-standard protein superfamilies; using recommended settings, families were assigned to the correct superfamilies with 0.17% false positive and no false negative assignments.

SUBMITTER: Hamady M 

PROVIDER: S-EPMC2575518 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature

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MotifCluster: an interactive online tool for clustering and visualizing sequences using shared motifs.

Hamady Micah M   Widmann Jeremy J   Copley Shelley D SD   Knight Rob R  

Genome biology 20080815 8


MotifCluster finds related motifs in a set of sequences, and clusters the sequences into families using the motifs they contain. MotifCluster, at http://bmf.colorado.edu/motifcluster, lets users test whether proteins are related, cluster sequences by shared conserved motifs, and visualize motifs mapped onto trees, sequences and three-dimensional structures. We demonstrate MotifCluster's accuracy using gold-standard protein superfamilies; using recommended settings, families were assigned to the  ...[more]

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