Ontology highlight
ABSTRACT:
SUBMITTER: Lin HS
PROVIDER: S-EPMC2575765 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Lin Ho-Sheng HS Talwar Harvinder S HS Tarca Adi L AL Ionan Alexei A Chatterjee Madhumita M Ye Bin B Wojciechowski Jerzy J Mohapatra Saroj S Basson Marc D MD Yoo George H GH Peshek Brian B Lonardo Fulvio F Pan Chuan-Ju G CJ Folbe Adam J AJ Draghici Sorin S Abrams Judith J Tainsky Michael A MA
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20071101 11
Currently, no effective tool exists for screening or early diagnosis of head and neck squamous cell carcinoma (HNSCC). Here, we describe an approach for cancer detection based on analysis of patterns of serum immunoreactivity against a panel of biomarkers selected using microarray-based serologic profiling and specialized bioinformatics. We biopanned phage display libraries derived from three different HNSCC tissues to generate 5,133 selectively cloned tumor antigens. Based on their differential ...[more]