Lock-and-key mechanisms of cerebellar memory recall based on rebound currents.

ABSTRACT: A basic question for theories of learning and memory is whether neuronal plasticity suffices to guide proper memory recall. Alternatively, information processing that is additional to readout of stored memories might occur during recall. We formulate a "lock-and-key" hypothesis regarding cerebellum-dependent motor memory in which successful learning shapes neural activity to match a temporal filter that prevents expression of stored but inappropriate motor responses. Thus, neuronal plasticity by itself is necessary but not sufficient to modify motor behavior. We explored this idea through computational studies of two cerebellar behaviors and examined whether deep cerebellar and vestibular nuclei neurons can filter signals from Purkinje cells that would otherwise drive inappropriate motor r

SUBMITTER: Wetmore DZ 

PROVIDER: S-EPMC2576199 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature