Ontology highlight
ABSTRACT:
SUBMITTER: Giles K
PROVIDER: S-EPMC2576443 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Giles Kurt K Glidden David V DV Beckwith Robyn R Seoanes Rose R Peretz David D DeArmond Stephen J SJ Prusiner Stanley B SB
PLoS pathogens 20081114 11
Distinct prion strains often exhibit different incubation periods and patterns of neuropathological lesions. Strain characteristics are generally retained upon intraspecies transmission, but may change on transmission to another species. We investigated the inactivation of two related prions strains: BSE prions from cattle and mouse-passaged BSE prions, termed 301V. Inactivation was manipulated by exposure to sodium dodecyl sulfate (SDS), variations in pH, and different temperatures. Infectivity ...[more]