African swine fever virus protein p30 interaction with heterogeneous nuclear ribonucleoprotein K (hnRNP-K) during infection.
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ABSTRACT:
SUBMITTER: Hernaez B
PROVIDER: S-EPMC2577129 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
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African swine fever virus protein p30 interaction with heterogeneous nuclear ribonucleoprotein K (hnRNP-K) during infection.
Hernaez Bruno B Escribano Jose M JM Alonso Covadonga C
FEBS letters 20080905 23-24
Heterogeneous nuclear ribonucleoprotein K (hnRNP-K) was identified as interacting cellular protein with the abundant immediate early protein p30 from African swine fever virus (ASFV) in a macrophage cDNA library screening. The interacting regions of hnRNP-K with p30 were established within residues 35-197, which represent KH1 and KH2 domains responsible for RNA binding. Colocalization of hnRNP-K and p30 was observed mainly in the nucleus, but not in the cytoplasm of infected cells and infection ...[more]
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