Ontology highlight
ABSTRACT:
SUBMITTER: Kang W
PROVIDER: S-EPMC2577233 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Kang Weiqun W Saqui-Salces Milena M Zavros Yana Y Merchant Juanita L JL
Biochemical and biophysical research communications 20080917 3
We previously showed that antral gastric tumors develop in gastrin-deficient (Gas(-/-)) mice. Therefore Gas(-/-) mice were studied sequentially over 12 months to identify molecular mechanisms underlying gastric transformation. Fundic atrophy developed by 9 months in Gas(-/-) mice. Antral mucosal hyperplasia developed coincident with the focal loss of TFF1 and Muc5AC. Microarray analysis of 12 month Gas(-/-) tumors revealed an increase in follistatin, an activin/BMP antagonist. We found that elev ...[more]