Unknown

Dataset Information

0

Induction of follistatin precedes gastric transformation in gastrin deficient mice.


ABSTRACT: We previously showed that antral gastric tumors develop in gastrin-deficient (Gas(-/-)) mice. Therefore Gas(-/-) mice were studied sequentially over 12 months to identify molecular mechanisms underlying gastric transformation. Fundic atrophy developed by 9 months in Gas(-/-) mice. Antral mucosal hyperplasia developed coincident with the focal loss of TFF1 and Muc5AC. Microarray analysis of 12 month Gas(-/-) tumors revealed an increase in follistatin, an activin/BMP antagonist. We found that elevated follistatin expression occurred in the proliferative neck zone of hyperplastic antrums, in antral tumors of Gas(-/-) mice, and also in human gastric cancers. Follistatin induced cyclin D1 and the trefoil factors TFF1 and TFF2 in a gastric cancer cell line. We concluded that antral hyperplasia in Gas(-/-) mice involves amplification of mucous cell lineages due to follistatin, suggesting its role in the development of antral gastric tumors.

SUBMITTER: Kang W 

PROVIDER: S-EPMC2577233 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

Induction of follistatin precedes gastric transformation in gastrin deficient mice.

Kang Weiqun W   Saqui-Salces Milena M   Zavros Yana Y   Merchant Juanita L JL  

Biochemical and biophysical research communications 20080917 3


We previously showed that antral gastric tumors develop in gastrin-deficient (Gas(-/-)) mice. Therefore Gas(-/-) mice were studied sequentially over 12 months to identify molecular mechanisms underlying gastric transformation. Fundic atrophy developed by 9 months in Gas(-/-) mice. Antral mucosal hyperplasia developed coincident with the focal loss of TFF1 and Muc5AC. Microarray analysis of 12 month Gas(-/-) tumors revealed an increase in follistatin, an activin/BMP antagonist. We found that elev  ...[more]

Similar Datasets

| S-EPMC6109697 | biostudies-literature
| S-EPMC4727015 | biostudies-literature
| S-EPMC2708822 | biostudies-other
| S-EPMC2697940 | biostudies-literature
2014-09-01 | E-MTAB-2824 | biostudies-arrayexpress
| S-EPMC5537064 | biostudies-literature
| S-EPMC10998378 | biostudies-literature
| S-EPMC6019449 | biostudies-literature
| S-EPMC2211944 | biostudies-literature
| S-EPMC2887754 | biostudies-literature