Mechanotransducers in rat pulpal afferents.
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ABSTRACT:
SUBMITTER: Hermanstyne TO
PROVIDER: S-EPMC2577312 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Publications
Mechanotransducers in rat pulpal afferents.
Hermanstyne T O TO Markowitz K K Fan L L Gold M S MS
Journal of dental research 20080901 9
The hydrodynamic theory suggests that pain associated with stimulation of a sensitive tooth ultimately involves mechanotransduction as a consequence of fluid movement within exposed dentinal tubules. To determine whether putative mechanotransducers could underlie mechanotransduction in pulpal afferents, we used a single-cell PCR approach to screen retrogradely labeled pulpal afferents. The presence of mRNA encoding BNC-1, ASIC3, TRPV4, TRPA1, the alpha, beta, and gamma subunits of ENaC, and the ...[more]
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