Dataset Information

Design and baseline characteristics from the KAN-QUIT disease management intervention for rural smokers in primary care.

ABSTRACT:

Objective

To describe the design, implementation, baseline data, and feasibility of establishing a disease management program for smoking cessation in rural primary care.

Method

The study is a randomized clinical trial evaluating a disease management program for smoking cessation. The intervention combined pharmacotherapy, telephone counseling, and physician feedback, and repeated intervention over two years. The program began in 2004 and was implemented in 50 primary care clinics across the State of Kansas.

Results

Of eligible patients, 73% were interested in study participation. 750 enrolled participants were predominantly Caucasian, female, employed, and averaged 47.2 years of age (SD=13.1). In addition to smoking, 427 (57%) had at least one additional major risk factor for cardiovascular disease (diabetes, hypertension, high cholesterol, heart disease or stroke). Participants smoked on average 23.7 (SD=10.4) cigarettes per day, were contemplating (61%) or preparing to quit (30%), were highly motivated and confident of their ability to quit smoking, and reported seeing their physicians multiple times in the past twelve months (Median=3.50; Mean=5.48; SD=6.58).

Conclusion

Initial findings demonstrate the willingness of patients to enroll in a two-year disease management program to address nicotine dependence, even among patients not ready to make a quit attempt. These findings support the feasibility of identifying and enrolling rural smokers within the primary care setting.

SUBMITTER: Cox LS

PROVIDER: S-EPMC2577567 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature

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Publications

Design and baseline characteristics from the KAN-QUIT disease management intervention for rural smokers in primary care.

Cox Lisa Sanderson LS Cupertino Ana-Paula AP Mussulman Laura M LM Nazir Niaman N Greiner K Allen KA Mahnken Jonathan D JD Ahluwalia Jasjit S JS Ellerbeck Edward F EF

Preventive medicine 20080503 2

<h4>Objective</h4>To describe the design, implementation, baseline data, and feasibility of establishing a disease management program for smoking cessation in rural primary care.<h4>Method</h4>The study is a randomized clinical trial evaluating a disease management program for smoking cessation. The intervention combined pharmacotherapy, telephone counseling, and physician feedback, and repeated intervention over two years. The program began in 2004 and was implemented in 50 primary care clinics ...[more]

PMID: 18544464

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Project description:African Americans experience significant tobacco-related health disparities despite the fact that over half of African American smokers are light smokers (use ? 10 cigarettes per day). African Americans have been under-represented in smoking cessation research, and few studies have evaluated treatment for light smokers. This paper describes the study design, measures, and baseline characteristics from Kick It at Swope III (KIS-III), the first treatment study of bupropion for African American light smokers.Five hundred forty African American light smokers were randomly assigned to receive bupropion (150 mg bid) (n = 270) or placebo (n = 270) for 7 weeks. All participants received written materials and health education counseling. Participants responded to survey items and provided blood samples for evaluation of phenotype and genotype of CYP2A6 and CYP2B6 enzymes involved in nicotine and bupropion metabolism. Primary outcome was cotinine-verified 7-day point prevalence smoking abstinence at Week 26 follow-up.Of 2,628 individuals screened, 540 were eligible, consented, and randomized to treatment. Participants had a mean age of 46.5 years and 66.1% were women. Participants smoked an average of 8.0 cigarettes per day, had a mean exhaled carbon monoxide of 16.4 ppm (range 1-55) and a mean serum cotinine of 275.8 ng/ml. The mean Fagerström Test for Nicotine Dependence was 3.2, and 72.2% of participants smoked within 30 minutes of waking. The average number of quit attempts in the past year was 3.7 and 24.2% reported using pharmacotherapy in their most recent quit attempt. Motivation and confidence to quit were high.KIS-III is the first study designed to examine both nicotine and bupropion metabolism, evaluating CYP2A6 and CYP2B6 phenotype and genotype in conjunction with psychosocial factors, in the context of treatment of African American light smokers. Of 1629 smokers screened for study participation, only 18 (1.1%) were ineligible to participate in the study because they refused blood draws, demonstrating the feasibility of recruiting and enrolling African American light smokers into a clinical treatment trial involving biological data collection and genetic analyses. Future evaluation of individual factors associated with treatment outcome will contribute to advancing tailored tobacco use treatment with the goal of enhancing treatment and reducing health disparities for African American light smokers.ClinicalTrials.gov: NCT00666978.

Dataset Information

Design and baseline characteristics from the KAN-QUIT disease management intervention for rural smokers in primary care.

Objective

Method

Results

Conclusion

Publications

Design and baseline characteristics from the KAN-QUIT disease management intervention for rural smokers in primary care.

Similar Datasets

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