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Nanoparticles for two-photon photodynamic therapy in living cells.

ABSTRACT: We describe here a nontoxic two-photon photodynamic nanoparticle platform and its cellular application. We demonstrate that the dye's potential toxicity can be circumvented by its permanent encapsulation into a biocompatible nanoparticle polymer matrix; this was examined by dye leaching experiments and confirmed by cell uptake experiments. Infrared two-photon nanoplatform phototoxicity was demonstrated for rat C6 glioma cells, while the controls showed no dark toxicity for these living cells.

SUBMITTER: Gao D

PROVIDER: S-EPMC2577608 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature

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Nanoparticles for two-photon photodynamic therapy in living cells.

Gao De D Agayan Rodney R RR Xu Hao H Philbert Martin A MA Kopelman Raoul R

Nano letters 20061101 11

We describe here a nontoxic two-photon photodynamic nanoparticle platform and its cellular application. We demonstrate that the dye's potential toxicity can be circumvented by its permanent encapsulation into a biocompatible nanoparticle polymer matrix; this was examined by dye leaching experiments and confirmed by cell uptake experiments. Infrared two-photon nanoplatform phototoxicity was demonstrated for rat C6 glioma cells, while the controls showed no dark toxicity for these living cells. ...[more]

PMID: 17090062

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