Integrins in angiogenesis and lymphangiogenesis.
Ontology highlight
ABSTRACT:
SUBMITTER: Avraamides CJ
PROVIDER: S-EPMC2577722 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Publications
Integrins in angiogenesis and lymphangiogenesis.
Avraamides Christie J CJ Garmy-Susini Barbara B Varner Judith A JA
Nature reviews. Cancer 20080522 8
Blood vessels promote tumour growth, and both blood and lymphatic vessels facilitate tumour metastasis by serving as conduits for the transport of tumour cells to new sites. Angiogenesis and lymphangiogenesis are regulated by integrins, which are members of a family of cell surface receptors whose ligands are extracellular matrix proteins and immunoglobulin superfamily molecules. Select integrins promote endothelial cell migration and survival during angiogenesis and lymphangiogenesis, whereas o ...[more]
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