Ontology highlight
ABSTRACT:
SUBMITTER: Lukashev D
PROVIDER: S-EPMC2577919 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Lukashev Dmitriy D Sitkovsky Michail M
Human immunology 20080611 7
Hypoxia-inducible factor-1alpha (HIF-1alpha) is critical not only in the regulation of oxygen homeostasis but also in the regulation of innate and adaptive immune systems. We previously reported that T-cell receptor-mediated activation of T cells in mice leads to the expression of an alternative isoform of HIF-1alpha that inhibits activated T cells in a delayed negative feed-back manner. In this paper, we describe a novel mRNA isoform of human HIF-1alpha that is upregulated in peripheral T lymph ...[more]