Ontology highlight
ABSTRACT:
SUBMITTER: Naylor J
PROVIDER: S-EPMC2579657 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Naylor J J Milligan C J CJ Zeng F F Jones C C Beech D J DJ
British journal of pharmacology 20080707 4
<h4>Background and purpose</h4>Isoform-specific ion channel blockers are useful for target validation in drug discovery and can provide the basis for new therapeutic agents and aid in determination of physiological functions of ion channels. The aim of this study was to generate a specific blocker of human TRPM3 channels as a tool to help investigations of this member of the TRP cationic channel family.<h4>Experimental approach</h4>A polyclonal antibody (TM3E3) was made to a conserved peptide of ...[more]