Ontology highlight
ABSTRACT:
SUBMITTER: Batchelor E
PROVIDER: S-EPMC2579769 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Batchelor Eric E Mock Caroline S CS Bhan Irun I Loewer Alexander A Lahav Galit G
Molecular cell 20080501 3
DNA damage initiates a series of p53 pulses. Although much is known about the interactions surrounding p53, little is known about which interactions contribute to p53's dynamical behavior. The simplest explanation is that these pulses are oscillations intrinsic to the p53/Mdm2 negative feedback loop. Here we present evidence that this simple mechanism is insufficient to explain p53 pulses; we show that p53 pulses are externally driven by pulses in the upstream signaling kinases, ATM and Chk2, an ...[more]