Ontology highlight
ABSTRACT:
SUBMITTER: Wu X
PROVIDER: S-EPMC2579941 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Wu Xuefei X Chen Po See PS Dallas Shannon S Wilson Belinda B Block Michelle L ML Wang Chao-Chuan CC Kinyamu Harriet H Lu Nick N Gao Xi X Leng Yan Y Chuang De-Maw DM Zhang Wanqin W Lu Ru Band RB Hong Jau-Shyong JS
The international journal of neuropsychopharmacology 20080709 8
Parkinson's disease (PD) is characterized by the selective and progressive loss of dopaminergic (DA) neurons in the midbrain substantia nigra. Currently, available treatment is unable to alter PD progression. Previously, we demonstrated that valproic acid (VPA), a mood stabilizer, anticonvulsant and histone deacetylase (HDAC) inhibitor, increases the expression of glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) in astrocytes to protect DA neurons i ...[more]