A stem cell gene expression profile of human squamous cell carcinomas.
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ABSTRACT:
SUBMITTER: Jensen KB
PROVIDER: S-EPMC2580815 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Publications
A stem cell gene expression profile of human squamous cell carcinomas.
Jensen Kim B KB Jones Judith J Watt Fiona M FM
Cancer letters 20080726 1
To investigate the relationship between stem cells in normal epithelium and in squamous cell carcinomas (SCCs), we examined expression of a panel of human epidermal stem cell markers in SCCs and SCC cell lines. Markers that are co-expressed in normal stem cells were not co-expressed in SCC. Downregulation of two markers, Lrig1 and MAP4, and upregulation of a third, MCSP, correlated with poor differentiation status and increased proliferation in primary tumours. We conclude that SCCs do not refle ...[more]
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